Three major challenges, include climate change, water resource reduction and desertification. The preparation of daily or up-to-date maps of salinity and mineral changes can play an important role in the proper utilization of water resources Underground water is the most important source of water supply for agriculture in arid and semi-arid areas.For optimal management of water resources as well as maintaining and improving their quality, Location, volume and pattern data of water quality is needed in each specific geographic area. The aim of this study was to determine the most appropriate interpolation method and spatial analysis to evaluation of the groundwater salinity in Great Plains Yazd - Ardakan which is located in the center Yazd province. In order to study the salinity changes of groundwater in this area, the data of 18 years old (1376 to 1392) were used for salinity of the district water wells. After normalization and correction of incomplete data using + GS software best variogram model was chosen. extrapolated the most appropriate method of Geostatistical methods, kriging methods (ordinary) algorithm due to high value (R2) and low error (RSS) to prepare maps And finally salinity maps, GIS software changes and limitations in drawing groundwater salinity maps. Salinity maps show that ultra-high salinity (above 8 dS / m) in the central, north and northeastern parts of the area due to the construction of multiple wells and a long harvest period, as well as in parts of the south-east is located. The western and southwest margins consist of low salinity (less than 2 dS / m) and the rest of the basin is medium to high (4 to 8 dS / m) salinity.