In the current century, the increase in population and environmental pollution has made more pay attention to the use of new and renewable energies, including wind.One of the renewable energy sources that is currently being expanding is energy frome the wind. The specific geographic location of Iran has made it possible to use this clean energy and it makes it economical. In the present study, the daily and hourly wind speed and direction data from 1987 to 2015 were used to determine the potential of wind energy in Kavir, desert and Makran coast regions. After quantitative and qualitative control of the data, the monthly and hourly mean wind speed and their variability were calculated. Also, maps of spatial variations of wind speed were drawn and using spatial analysis methods, a potential wind power map was prepared in the study area. The results showed that the provinces of Kerman, Sistan and Baluchestan, Hormozgan, South of South Khorasan, and parts of eastern and southern of Yazd are among the areas susceptible to installing wind turbines and obtaining energy from the wind. Based on the results, the maximum wind speed at the study area occurs in the early hours of the day until early afternoon (9 am to 15 pm), resulting in the highest amount of energy during this time interval can be extracted. The specific climatic and geographical features of these areas have caused the permanent winds to be fairly strong throughout the day and have a high potential for wind energy.