The phenomenon of dust is one of the important climate hazards in arid and semi-arid regions of the world, which causes human and financial losses. In recent decades, due to the mismanagement of water resources in Iran, dust has increased in some areas and has affected many cities and villages. One of the regions that is most affected by this harmful phenomenon is Khuzestan province. This study examines the occurrence frequency and zoning of dust. For this purpose, hourly data of dust in 15 synoptic stations of the province for the period of 2000-2016 were received from the Meteorological Organization. The frequency of dust days for each station was extracted in different seasons, and the number of dust days in the province was zoned using the method of polynomial functions of the spline model. The results showed that the frequency of trans-local and local dust in Khuzestan province is 83 and 17 percent, respectively. Also, in the mentioned time frame, Safiabad station in the north of the province experienced the most trans-local dust and Bostan station in the west of the province experienced the most local dust, and the eastern and northeastern regions of the province had the least dusty days. The years 2017-2018 experienced the most trans-local dust and the years 2011-2021 experienced the most local dust. Also, the dry period and the spring season have the highest occurrence of local and trans-local dust.