Changes in water resources and the subsequent structure of ecosystems can have adverse effects on human societies. These effects can manifest in security issues, the provision of basic needs, and social and cultural relations. In this context, the drying up of Lake Urmia will have detrimental effects on the economic, social, environmental, and political-administrative structure of the country.The present article uses a descriptive-analytical method to seek a spatial explanation of the consequences of the drying up of Lake Urmia and strategies for the lake's restoration. Data collection was carried out through survey and library studies. The statistical population of the research is an elite panel consisting of 60 people (30 experts and 30 executives), who were selected using a snowball sampling method. The structural interaction approach with Mic Mac software and the interactive interaction approach with Scenario Wizard software were used to analyze the data.The findings of the research showed that according to the output of the structural interaction approach, the variables of decreasing water and soil resources, formation of ethnic conflicts, stagnation of housing and land prices, reduction of investment opportunities, reduction of production and income, reduction of people's purchasing power, damage to national unity and development, participation based on ethnic power and expansion, and socio-political gap, challenges in physical-spatial management, increase in unemployment, and reduction of tourist arrivals are the main consequences of the drying up of Lake Urmia.